[A retrospective cohort study on survival status of AIDS patients among 15 or above-year-olds in Henan province from 2008 to 2015]

Objective: To explore the survival status and affecting factors among patients diagnosed as AIDS in Henan province. Methods: Database of AIDS patients were downloaded from the China information system for disease prevention and control-AIDS with a retrospective study conducted. Inclusion criteria on patients would involve those diagnosed between 2008 and 2015 aged 15 years or above. Results: A total number of 25 525 HIV/AIDS patients were enrolled in this study. During the follow-up period the overall mortality among all the patients was 24.9%. Mortality of those having received the highly active antiretroviral treatment (HAART) was 14.4%. Proportion for the treatment coverage increased gradually from 72.1% in 2008 to 92.8% in 2015. The overall mortality rate dropped from 21.2% to 4.1% and the mortality of those having received HAART patients dropped from 9.2% to 2.6%. Results from the multiple factors analysis showed that factors as: CD(4)(+) T cell count (CD(4)) <50 cell/mul when the AIDS diagnosis was made (adjusted HR=2.45) were related to higher risk on mortality among HIV/AIDS patients. Patients having received HAART (adjusted HR=0.13) had lower risks on mortality. Among patients having received treatment results from the multiple factors analysis showed that factor as TMP-SMZ dosage being administered (adjusted HR=0.76) were related to low mortality risk. As for CD(4) counts of the patients the adjusted HRs were 1.26 in 50-cells/mul group and 1.97 in the <50 cells/mul group respectively when the diagnosis was made. Both groups had high risk on mortality patients with lower baseline CD(4) counts (adjusted HR were 1.44 1.84 in 50-cells/mul and <50 cells/mul groups respectively) seemed to have higher risk on mortality. Conclusions: Antiretroviral therapy appeared an important factor that affecting the survival of HIV/AIDS patients. CD(4) count test early identifying and treating the AIDS patients together with providing TMP-SMZ prevention and treatment programs were important approaches in extending the survival time so as to reduce the death rates from AIDS related illnesses.