Use of microbleeding and an ultrathin endoscope to assess gastric mucosal protection by famotidine

Abstract We have developed an ultrathin endoscope for repeated endoscopy in unsedated subjects and used it with assessment of bleeding rates to investigate aspirin-induced gastric mucosal injury and its prevention by famotidine. Compared with placebo, 900 mg of aspirin b.i.d. taken for 48 h caused significant endoscopie injury (median grade 3.5, interquartile range 2–4, modified Lanza scale, p