Mitochondrial Dysfunction and Immune Activation are Detectable in Early Alzheimer's Disease Blood

Katie Lunnona,b,1, Zina Ibrahima,b,1, Petroula Proitsia,b, Anbarasu Lourdusamya,b, Stephen Newhousea,b, Martina Sattleckera,b, Simon Furneya,b,3, Muzamil Saleema,b, Hilkka Soininenc, Iwona Kloszewskad, Patrizia Mecoccie, Magda Tsolakif , Bruno Vellasg, Giovanni Coppolah, Daniel Geschwindh, Andrew Simmonsa,b, Simon Lovestonea,b, Richard Dobsona,b,2, Angela Hodgesa,b,2,∗ and on Behalf of the AddNeuroMed Consortium aInstitute of Psychiatry, King’s Health Partners Centre for Neurodegeneration Research, King’s College London, London, UK bNIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King’s College London, London, UK cDepartment of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland dMedical University of Lodz, Lodz, Poland eInstitute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy f3rd Department of Neurology, “G. Papanicolaou” Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece gINSERM U 558, University of Toulouse, Toulouse, France hDepartment of Neurology, Programme inNeurogenetics, DavidGeffen School ofMedicine, University of California at Los Angeles, CA, USA