The Use of Colchicine in Cardiovascular Diseases – a Systematic Review

Abstract The medicinal properties of colchicine have been recognized for centuries. While previously used for gout and familial Mediterranean fever, its immune-modulating, anti-inflammatory, and antifibrotic effects are increasingly recognized to benefit cardiovascular disorders. In this systematic review, we summarize the current evidence on colchicine's effectiveness in 1) pericarditis, 2) coronary artery disease and 3) atrial fibrillation. We also discuss the safety, potential adverse effects and common drug interactions that should be considered during use.