Application of the Asymmetric Chelate Enolate Claisen Rearrangement to the Synthesis of Unsaturated Polyhydroxylated Amino Acids

Ester enolate Claisen rearrangement of chelated N -pro- tected chiral allylic amino acid esters results in the formation of polyhydroxylated γ , δ -unsaturated amino acids in good yields and with a high degree of chirality transfer.