Infection and transformation of Fν-2rr erythroprogenitor cells with Friend virus

Abstract Friend virus was used to infect and transform Fv-2 rr erythroprogenitor cells in vivo. The RB ( Fv-2 rr ) cell line was characteristic of Friend virus-induced cell lines in Fv-2 ss mice, i.e., it produced infectious Friend virus and synthesized hemoglobin. The RB ( Fv-2 rr ) cell line expressed the envelope protein of the spleen focus-forming virus (gp52) and a novel, related envelope protein (gp48). The results demonstrate that Fv-2 rr erythroprogenitor cells can be infected and transformed in vivo.