One-Pot Microwave-Assisted Synthesis of 3,4-Disubstituted 2-Quinolinones
2014
Abstract An improved one-pot synthesis of 3,4-disubstituted 2-quinolinones is described. The condensation of substituted 2-aminobenzophenone (or 2-aminophenyl alkyl ketone) with acid chlorides was carried out in the presence of triethylamine (or NaH) under microwave reaction conditions (150oC, 200 psi). The reactions were completed within minutes to produce 2-quinolinones in moderate to excellent yields and good purities. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]
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