Autologous platelets rich plasma a potential therapeutic modality for cervical regeneration in erosions and cervicitis prospective observational study in a teaching hospital of central India

Introduction: Biological reagent like PRP having strong anti–inflammatory and healing effect due to large number of growth factors and paracrine action thus plays a crucial role in cell protection, repairing and regeneration of epithelial tissues, curing deep seated inflammation thus protecting patient from long term consequences of chronic inflammation. Adult women worldover are commonly affected by cervicitis, Symptoms of it can be similar to vaginitis with persistent vaginal discharge, itching, heaviness and dysperiunea. It can be ca used by sexually transmitted infection as well as due to trauma, frequent douching and chemical irritants. This chronic in flammation of the cervix has a high recurrence rate due to its complex pathophysiology and leads to long term consequences like pelvic inflammatory disease, infertility, ectopic pregnancy, chronic pelvic pain, increased predisposition to HPV & HIV infection and even it can be a precursor of cervical cancer. Aim: To compare post treatment symptom relief and healing of damaged cervix in patient undergoing either conventional or PRP therapy for chronic cervicitis and erosions. Materials and Methods: This study was a single center, prospective observational study conducted at L N Medical college and research centre Bhopal M.P. A total of 120 patients with CC having similar symptoms were enrolled and out of which 60 randomly selected patients were given conventional treatment and remaining 6 0 were undergone PRP therapy. PRP was prepared from patients own blood in our institutional lab and injected immediately in the targeted areas of cervix at 3- 4 sites and result compared. Result: Better Clinical benefits and healed epithelium were observed o n follow up visits in the PRP treated patient as compared to conventional treatment in addition increased perception of recovery in patients within the prp group compared with the conventional group. No complications were reported in both therapy. Conclu