Chemical synthesis of human adiponectin(19–107) bearing post-translational glycosylation
2014
Abstract Human adiponectin(19–107), which consists of the variable region and the collagenous domain bearing post-translational modifications including glycosylation, was chemically synthesized for the first time. A glycoside of 5-hydroxylysine (Hyl) was incorporated using an α- d -glucopyranosyl-(1→2)-β- d -galactopyranosyl/Hyl-Gly building block in a benzyl-protected form by solid-phase peptide synthesis (SPPS). The molecule was assembled from four segments prepared by SPPS via native chemical ligation (NCL) and thioester methods.
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