AB0623 Pregnancy outcome in systemic lupus erythematosus: a retorspective study

Background Pregnancy represents a challenge for patients with systemic lupus erythematosus. One of the major risk is the occurence of a flare during pregnancy. The influences are mutual, and the risk of complications depend mostly on the disease activity in the last 6–12 months before pregnancy. Therefore, these patients need a multidisciplinary approach, the obstetrician should collaborate with the rheumatologist and nephorologist. Objectives To determinate the associations between disease activity and pregnancy outcomes, and the risk factors that predict pregnancy complications and flare. Methods We present a retrospective study conducted between january 2010 and december 2015. We enrolled 35 pregnant patients, diagnosed with SLE with ages between 21 and 46 years old. All patients were followed up since the beginning of the pregnancy until delivery. We tested the correlations between different biomarkers and clinical manifestations of disease activity and pregnancy outcomes. Results Maternal complications occured in 71,24% of the cases. The most common complications were: miscarriages, hematologic abnormalities (anemias, thrombocytopenia), premature birth and preeclampsia. The prematurity rate was 11% and most common delivery mode was the caesarian section. Also, the planning of the pregnancy was a predictor of a good fetal outcome (p=0,01). The presence of the lupus anticoagulant was associated with prematurity (p=0,046) at univaryate analysis. Antiphospholipidic syndrome was associated in 12% of the cases. Univaryate analysis did not show a correlation between the presence of the syndrome and any pregnancy outcome. Conclusions Pregnancy should be planned when the disease is in remission. Lupus nephritis, is an important risk factor for preeclampsia. Also, the presence of lupus anticoagulant is a risk factor for preeclampsia, and hematologic determinations during pregnancy. The risk factors for pregnancy complications were; secondary antiphospholipid syndrome, presence of lupus nephropaty, thrombocytopenia. our study showes that the exacerbations depend on the disease activity in the moment of conception. Disclosure of Interest None declared