Pharmacological Evaluation of Indigenous Antiurolithiatic Formulation Neeri (NRT-RF)

The Neeri NRT-RF was evaluated for its antiurolithiatic activity in rats. Calcium oxalate stones were induced by oral administration of ethylene glycol (0.75%) in male Wistar rats for 40 days, which is confirmed by the elevated level of several urinary parameters  (calcium, uric acid, magnesium in urine and urine output), serum parameters (calcium, creatinine, phosphorus, uric acid, magnesium, blood urea nitrogen) and kidney parameters (calcium, magnesium, phosphorus). Administration of Neeri NRT-RF for 25 days significantly decreased (to normal values) the elevated levels of serum, urine and kidney parameters and also prevented the deposition of crystals in tubules. Moreover, it showed antioxidant effect. In addition to this, NRT-RF (530.55 mg/kg) shows better results as compared to the standard drug disodium hydrogen citrate. Furthermore, histopathology also revealed that NRT-RF treated group of rats retained no or very less crystals deposition in the tissue, as compared to ethylene glycol treated group.