[Significance of plasmic homocysteine, folate and Vitamin B(12) in ulcerative colitis].

Objective To investigate the clinical significance of plasmic homocysteine (Hcy),folate (FA) and Vitamin B12 (VitB12) in patients with ulcerative colitis (UC). Methods Plasmic Hcy in 112 cases of UC patients and 110 controls were detected by HPLC-FD method. Plasmic FA, VitB12 in 76 cases of UC patients and 12 controls were detected by enzyme-linked immunosorbent assay (ELISA) method. Results The level of plasmic Hcy in UC patients was (11.27±7.26) μmol/L, significantly higher than that in controls [(8.19±4.81) μmol/L, P＜0.05], and was not significantly correlated with disease index, extent and duration of UC (P＞0.05). The level of FA and VitB12 in UC patients were (7.64±1.95) nmol/L and (108.64±32.22) pmol/L respectively, lower than those in controls [(9.14±1.23) nmol/L and (112.64±33.33) pmol/L,P＜0.05]. The level of plasmic Hcy was negatively correlated with the level of FA and VitB12 in UC patients (P＜0.05). The level of plasmic FA decreased to some extent with UC disease duration. Conclusion Plasmic Hcy is elevated in UC patients, which may be related to the decrease of FA and VitB12. Key words: Ulcerative colitis; Homocysteine; Folate; Vitamin B12