Synthesis and Evaluation of 17α-E-20-(Heteroaryl)norpregn-1,3,5 (10),20-tetraene-3,17β-diols [17α-(Heteroaryl)vinyl Estradiols] as Ligands for the Estrogen Receptor-α Ligand Binding Domain (ERα-LBD).
2012
A series of 17α-(heteroaryl)vinyl estradiols (III) is synthesized to evaluate the influence of heteroatom on the affinity and efficacy of estrogenic ligands for the estrogen receptor-alpha ligand binding domain.
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