Cosmetic method and evaluation method for improving skin conditions caused by suppression or enhancement of desquamating

Using a novel endogenous inhibitor to inhibit the activity of mesotrypsin, cosmetic method, the evaluation method of inhibiting and enhancement of desquamating for improving skin conditions caused by enhanced or suppressed in the desquamating, and stratum corneum It provides a method of screening for release accelerator-desquamating inhibitor. Serpin B12 inhibits the activity of mesotrypsin known as a starting protease desquamating, that functions as an endogenous trypsin inhibitor, based on the finding.