Long-Term Sequelae of Bisphosph onate-Induced Osteopetrosis: Metaphyseal Osteopenia, Osteosclerosis Fragility, and No vel Bone Modeling Defects After Drug Administration Ceases

FIGURE 6: A) Computed tomography of the patient’s knees in 2007, here showing the distal femur (Top), revealed widened metaphyses with thin cortices and a paucity of trabecular bone (arrow), compared to healthy boys of similar age (Bottom). In both distal femoral metaphyses there is expanded bone with a remarkable, large, central area (arrow) featuring a paucity of trabecular bone. B) Coronal sectioning of the CT shows the modeling defects and metaphyseal osteopenia and a vertical pattern of trabeculae. The subarticular epiphyseal bone is inexplicably dense (arrow). ABSTRACT