Syntheses and Evaluation of Acute and Chronic Anti-Inflammatory Activities of Some Novel Thieno-(2, 3-d)-Pyrimidin-4-(3H)-ones.

A new series (SRC1-C12) of 3-substituted amino-2-methyl thieno [2, 3- d] pyrimidin -4- (3H) -ones were synthesized from 2methyl-3-N-amino -5,6,7,8-tetrahydrobenzo thieno [2,3-d]pyrimidin-4-one in the present study. Elemental analysis, UV, IR, 1H NMR, and C,H & N analysis confirmed the structure of these newly synthesized compounds. All the compounds were investigated for acute (30mg/kg p.o) and chronic (10mg/kg p.o) anti-inflammatory activity using carrageenan induced rat paw edema model and carrageenan-induced granuloma air pouch model respectively. All the compounds exhibited significant (P<0.05) anti-inflammatory activity in acute model while in chronic model only compounds SR-C1-C7 exhibited significant activity (P < 0.05). In addition, the most active compounds were tested for their acute toxicity.