Nanoflow system for perfect regiocontrol in the Baeyer–Villiger oxidation by aqueous hydrogen peroxide using lowest concentration of a fluorous lanthanide catalyst

Abstract The scandium bis(perfluorooctanesulfonyl)amide-catalyzed Baeyer–Villiger reaction significantly increased the regioselectivity as well as the reaction rate by nanoflow system continuously controlled by a nanofeeder even in the lowest concentration of the catalyst (≪0.1 mol %). The Baeyer–Villiger reaction completed within few seconds as a contact time in the microcell to afford the lactone products high regioselectively without hydrolysis.