Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARδ-selective agonists
2007
Abstract To find novel PPARδ-selective agonists, we designed and synthesized phenylpropanoic acid derivatives bearing 6-substituted benzothiazoles. Optimization of this series led to the identification of a potent and selective PPARδ agonist 17 . Molecular modeling suggested that compound 17 occupies the Y-shaped pocket of PPARδ appropriately.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
28
References
14
Citations
NaN
KQI