Clinical value of an amplified electrophoretic determination of enolase isoenzymes in small cell lung carcinoma patients.
1989
Neurone specific enolase (NSE); ay and yy isoenzymes of the glycolytic enzyme enolase, is found in considerable quantity in serum of patients with small cell lung cancer (SCLC). The spectrophotometric measurement of serum enolase activity, plus the electrophoretic separation of isoenzymes (αα, αy and yy) using an amplification reaction constitute a simple method, the application of which has not yet been demonstrated. In patients, serum values of higher than 25 U/l of total enolase activity, with more than 10% NSE, were considered to be positive. Seventy patients diagnosed as SCLC were classified before treatment as having either limited (LD) or extensive (ED) disease, and after chemotherapy as being in complete (CR) or partial remission (PR), stable state (SS) or in relapse (R). The levels of enolase activity and NSE (M±SE) in these patients (enolase: 67±7 U/l, NSE 27±2%) were different from those in a control group of 19 patients with non-small cell lung cancer (enolase: 29±2 U/l, NSE: 7±1%) (p<0.001) a...
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