Chronic Administration of Hydroxylamine and Derivatives in Mice

SummaryLong-term administration of hydroxylamine, methoxyamine, or hydroxyurea to Swiss-Webster mice did not cause tumor formation. Hydroxylamine inhibited spontaneous formation of mammary tumors in female C3H mice. The principal toxic effects of hydroxylamine were anemia, splenomegaly and bone formation in the spleen.The authors appreciate the assistance of Mr. Gerome McDowell and Miss J. Zuefle in various phases of the experiments.