Statistical study of the Fisher-Race model for human Rh genetics.

The technique of chromosomal positioning of inheritable traits (C.P.I.T.) to project relative positions of two or more traits at more than one gene locus was employed to test the validity of the Fisher-Race model of Rh structure. The results of statistical analysis of two large samples of Rh phenotype distributions suggest that all models based on vertically related, linked alleles are invalid. On the basis of further analysis, Wiener's concept of the structure of the human Rh-Hr gene locus appears most valid among current hypotheses.