A handheld confocal microscope with MEMS-based flat-field scanning for fluorescence-guided surgery

Linpeng Wei,Chengbo Yin,Sanjeewa Abeytunge,Gary Peterson,Michael J. Mandella,Milind Rajadhyaksha,Nader Sanai,Jonathan T. C. Liu

A handheld confocal microscope with MEMS-based flat-field scanning for fluorescence-guided surgery

2019

Linpeng Wei
Chengbo Yin
Sanjeewa Abeytunge
Gary Peterson
Michael J. Mandella
Milind Rajadhyaksha
Nader Sanai
Jonathan T. C. Liu

We developed a handheld line-scanned dual-axis confocal microscope for real-time optical biopsy. The device utilizes a novel MEMS-based scanning mechanism for field-flattening, and provides high-speed (16 Hz) fluorescence imaging with sub-nuclear resolution in tissue.

Keywords:

Confocal microscopy
Optical Biopsy
Fluorescence-lifetime imaging microscopy
Biomedical engineering
Image processing
Microscopy
Confocal
Microscope
Deformable mirror
Materials science
Microelectromechanical systems

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