A panel of dynamic micromechanical biomarkers in the detection and differentiation of prostate cancer.

38 Background: Elasticity devices enable quantitative measurements and can reduce the need for operator interpretation. Our dynamic assessment enables micromechanical markers to be identified: amplitude ratio [AR], phase lag [PL] and mean ratio [MR], at specific frequencies. Aim: To assess the efficacy of a panel of dynamic micromechanical biomarkers for the detection of prostate cancer (Primary endpoint) (and differentiation of significant from insignificant disease (secondary endpoint)) in ex-vivo prostates and in patients, using a direct elasticity assessment probe (E-finger). Methods: Patients undergoing surgery for prostate cancer were enrolled into a prospective clinical study; exclusion criteria (previous TURP, 5ARI). Ex-vivo prostates were systematically assessed at multiple points on posterior surface. In-vivo testing was done using the probe attached to the index finger and assessing the prostate via DRE using 12 -16 different areas. Measurement points were marked and noted on final pathology to...