Game changers: why did the scale-up of HIV treatment work despite weak health systems?

Game changers are radical innovations that result in fundamental and durable changes. The global HIV program scale-up witnessed over the past decade has included some innovations that are not well appreciated. The willingness to rapidly adopt and implement innovations the flexibility and speed of program implementation and the readiness to re-examine professional roles are just a few of such game changers. However moving ahead further work is needed to enhance the quality of programs to energetically tackle HIV prevention to build on this success and to address other health threats that these same communities face.