231. Synchronous and metachronous bilateral breast cancer – A comparison of clinical, histopathological features of the first and second primary breast cancer and BRCA 1 and 2 mutations

Purpose To evaluate the clinical, histopathological features of the first and second primary breast cancer in patients with bilateral breast cancer and to determine the contribution of BRCA 1 and 2 mutations in BBC. Material and methods 131 patients treated at Institute of Oncology MCS Memorial in Gliwice between 1969–2002 developed bilateral breast cancer/BBC/. There were 39/29,7 %/synchronous and 92/70,3%/ metachronous BBC. BRCA 1 and 2 mutations analysis was performed in 92 patients. Results Mean age of diagnosis of cancer in SBBC and MBBC group was 52 and 46/p=0,002/. The proportion of early stage tumors was signiticantly higher in opposite side tumors compared to the first primary tumor in both groups /p Conclusions 1. A close follow-up policy enables detection the second breast cancer at an earlier stage than the primary one. 2. SBBC and MBBC seem to be different set of tumors in term of clinical characteristics and survival.