Synthesis of 1,5-benzothiazepines: Part XXX-Synthesis and antimicrobial studies of 10-substituted-6a, 7-dihydro-6 H -7-(4-fluorophenyl)-6-phenyl [1] benzopyrano [3,4- c ] [1,5] benzothiazepines

Flavindogenide, 3-(4-fluorobenzylidene)-flavanone has been reacted with six 5-suhsliluted-2-aminobenzenethiols, the substituunts being halogens as fluoro, chloro bromo, alkyl as methyl and alkoxyl as methoxyl and ethoxyl, to obtain a series of six new compounds, 10-substituted-6a,7-dihydro-6H-7-(4-fluorophenyl)-6-phenyl[1] benzopyrano[3,4-c][1,5]benzothiazepines 3;i-f. The products arc characterized on the basis of ,icroanalytical data for elements and IR. 1 H NMR, 19 F NMR and mass spectral studies. All the synthesized compounds have been evaluated for their antimierobial activity against the bacteria Escherichia coli and GFC (Alleromonas tetraodonis - a new Gram-negative bacteria family) and fungi, Aspergillus niger, A. flavus and Curvularia humata, All the compounds showed equal/greater bactericidal activity but for 3d showing lesser activity against E. coil and 3e against GFC.