Влияние хронической почечной недостаточности на состояние слизистой оболочки полости рта в эксперименте

The morphological changes of a mucous membrane in rat oral cavity at the chronic renal insufficiency (CRI) of various degrees were studied by methods of light microscopy. It was revealed that in 6 months after modeling of easy or mild CRI the mucous membrane in an oral cavity was diffuse infiltrated by leukocytes, the volume density of blood and lymphatic vessels was increased. Rats with high grade of CRI have an atrophy and hyperkeratoses of mouth epithelium, sclerosis of a mucous membrane was detect, the number of leukocytes considerably increased, first of all, neutrophils, monocytes, macrophages, small leukocytic infiltrates were formed. Besides, at mild or high grade of CRI in mucous membrane of an oral cavity the quantity of eosinophils and plasmatic cells increases that points to possible presence of a considerable allergic component in initiation and maintenance of inflammation in mouth tissues at CRI.