EXPRESS: Circulating Markers of Angiogenesis and Endotheliopathy in COVID-19

Despite over 30 million infected and 800,000 deaths, the pathophysiological factors that determine the wide spectrum of clinical outcomes in COVID-19 remain inadequately defined Importantly, patients with underlying cardiovascular disease have been found to have worse clinical outcomes (1), and autopsy findings of endotheliopathy in COVID-19 have accumulated (2) Nonetheless, circulating markers of endothelial or vascular injury associated with disease severity and mortality have not been reliably established To address this limitation and better understand COVID-19 pathogenesis, we report plasma profiling of factors related to the vascular system from patients admitted to our Hospital with confirmed COVID-19 diagnosis, which revealed significant increases in markers of angiogenesis and endotheliopathy in hospitalized patients