CORRELATION OF INCREASED SERUM ADIPSIN WITH INCREASED CARDIOVASCULAR RISKS IN ADULT PATIENTS WITH GROWTH HORMONE DEFICIENCY

Abstract Objective: Adult growth hormone deficiency (AGHD) patients have an increased cardiovascular morbidity and mortality. Adipsin as an adipokine that is significantly correlated with metabolism disease, especially in people with obesity. The objective of our study was to compare AGHD patients with healthy subjects to evaluate whether adipsin levels are closely related to glycolipid metabolism and cardiovascular risks in AGHD patients. Methods: Our study included 88 AGHD patients and 88 age-, weight- and BMI-matched healthy subjects. Anthropometric parameters such as body mass index, waist circumference, and blood pressure were measured. Biochemical indicators such as serum adipsin, lipids and fasting insulin levels were determined. Results: Adipsin levels in AGHD patients were significantly increased compared to levels of the control group [11567.29 (9856.46–13360.60) ng/mL vs. 9127.86 (8061.82–10647.06) ng/mL, p=0.000]. Increased serum adipsin levels are correlated with cardiovascular risk factors s...