Microwave synthesis, characterization and antimicrobial study of new pyrazolyl-oxopropyl-quinazolin-4(3H)-one derivatives

Abstract Heterocyclic compounds containing pyrazolyl-oxopropyl-quinazolin-4(3 H )-one are reported to possess significant biological activity. Syntheses of 6-bromo-2-(3-chloro-2-oxopropyl)-3-(4-fluorophenyl)quinazolin-4(3 H )-one 2 6-bromo-3-(4-fluorophenyl)-2-(3-hydrazinyl-2-oxopropyl)quinazolin-4(3 H )-one 3 and 6-bromo-2-(3-(3-(4-(1-(2-chlorophenyl)-3-methyl-1 H -pyrazol-5(4 H )-ylideneamino)phenyl)-5-(substituted phenyl)-4,5-dihydro-1 H -pyrazol-1-yl)-2-oxopropyl)-3-(4-fluorophenyl)quinazolin-4(3 H )-one 5a – j using microwave irradiation have been described. These compounds have been characterized on the basis of the UV, IR, 1 H NMR, 13 C NMR, Mass and elemental analysis. Compounds have been evaluated for their antimicrobial activity.