Формування знань про токсиканти як складові хімічної безпеки у майбутніх лікарів під час вивчення біоорганічної та біологічної хімії

Chemical safety of treating chemical substances is key problems that unite the international community. Realization of the modern model of chemical safety provides the coordinated work of legal, economic, ecological-hygienic, prophylactic and educational components. A doctor of ХХІ century must have knowledge about modern approaches to classification of dangers and marking chemical substances, be able to ground toxicological properties and molecular mechanisms of the effect of toxicants, estimate risks as to using chemical substances of inorganic and organic nature, give medical care to persons, who suffered as a result of the influence of chemical compounds. The paper theoretically grounds methodical approaches to formation of knowledge about inorganic toxicants as a component of chemical safety in future doctors at studying bioorganic and biological chemistry. There is presented the analysis of the learning program on biological chemistry, and it was established, that formation of knowledge about inorganic toxicants as a component of chemical safety can be realized at studying such topics as enzymes, bases of bioenergetics, metabolism of amino acids, bases of molecular genetics, biochemistry of human nutrition, biochemistry of blood and liver. It was proved, that “Biochemistry of the liver” is a generalizing section as to problems of chemical safety in the course of bioorganic and biological chemistry. The structural-logic scheme of formation of knowledge about dangerous chemical substances is described. There was realized the purposeful pedagogical influence as formation of knowledge about organic and inorganic toxicants as components of chemical safety, in the course of “Bioorganic and biological chemistry” at studying the topic “Investigation of processes of biotransformation of xenobiotics and endogenous toxins. Microsomal oxidation by cytochrome Р-450”. There were developed two video-collections “Modern approaches to classification and marking of chemical substances”, “Biotransformation of xenobiotics and endogenous toxins” and cases “Toxicants in the context of chemical safety”. The developed materials were probated in the course of biological chemistry at training future doctors in the National medical university, named after O.O. Bogomolets