Abstract 770: Association of YAP expression with colorectal cancer progression.

YAP, a crucial transcriptional coactivator in the Hippo signaling pathway, is upregulated in several human tumors and suggested to promote tumor progression. However, its expression level and role in colorectal cancer (CRC) remain unknown. In this study, YAP expression and the correlation between YAP expression and CRC clinical features were investigated. Quantitative real-time polymerase chain reaction and Western blotting were performed on 30 matched pairs of fresh CRC tissues and adjacent normal mucosae from 30 CRC patients. Immunohistochemical analysis was performed on 116 matched pairs of paraffin-embedded CRC tissues and adjacent normal mucosae, as well as in 73 cases of metastatic lymph nodes. Our results showed YAP expression level in CRC or lymphatic metastatic tissues was clearly higher than that in normal mucosae (P Citation Format: Daxing Xie, Xiangyang Wang, Jiang Min, Xiaolan Li, Jubo Hu, Jianping Gong. Association of YAP expression with colorectal cancer progression. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 770. doi:10.1158/1538-7445.AM2013-770 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.