Utilizing quantitative multiplex immunofluorescence to characterize paracrine interactions within the tumor-immune landscape of metastatic melanoma.

Rachel L. G. Maus,Alexey A. Leontovich,Raymond Moore,Wendy K. Nevala,Thomas J. Flotte,Susan M. Geyer,Ruifeng Guo,Jill Schimke,Betty Dicke,Svetomir N. Markovic

Utilizing quantitative multiplex immunofluorescence to characterize paracrine interactions within the tumor-immune landscape of metastatic melanoma.

2020

Rachel L. G. Maus
Alexey A. Leontovich
Raymond Moore
Wendy K. Nevala
Thomas J. Flotte
Susan M. Geyer
Ruifeng Guo
Jill Schimke
Betty Dicke
Svetomir N. Markovic

e15184Background: Clinical responses to anti-PD1 immunotherapy in patients with metastatic melanoma (MM) remain challenging to predict. This clinical heterogeneity is also reflected in the tumor-im...

Keywords:

Multiplex
Immune system
Paracrine signalling
Immunofluorescence
Pathology
metastatic melanoma
Medicine

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