The suitability of a combined inulin/PAH retard tablet for measuring renal functions in the conscious rat

As a further step in the development of implantable retard systems for simultaneous delivery of inulin and PAH, a system based on Eudragit® matrix retard tablet has been deviced. It should be able to release a sufficient amount of both substances to maintain constant and well measurable serum and urine concentration in the 36 hours interval between 12–48 hours p.o. The feasibility of the technique was checked by monitoring the behaviour of renal function after administration of a permanent adrenaline application, which we used as a well defined noxa.