Efficacy of TIGIT in the cancer immune cycle

Immunotherapy is a therapeutic method that uses the immune system to inhibit tumor activity and kill tumor cells.It has been proved to be effective in the treatment of various malignant tumors.In general, the immune system can recognize and kill the abnormal cells, while the tumor cells can produce a variety of mechanisms to inhibit the immune system, resulting into the incomplete death of the cells.TIGIT is a type of inhibitory receptor containing T cell immunoglobulin and immunoreceptor protein tyrosine inhibitory motif (ITIM) protein domain.This paper discusses the role of TIGIT in limiting antitumor responses and reviews the mechanisms of action during the cancer immunity cycles. Key words: TIGIT; Tumor immune cycle; Dendritic cell; Natural killer cell; T cell