Kinetic analysis of oxidation of dopamine by sodium N-chlorobenzenesulphonamide in perchloric acid medium: A mechanistic approach

Kinetics of oxidation of dopamine (DPM) by sodium N-chlorobenzenesulphonamide (chloramine-B or CAB) in perchloric acid medium has been studied at 40°C. The rate shows first order dependence in CABo fractional order in DPMo, and inverse fractional order in H+. The effects of dielectric constant and solvent isotope have been studied. Michaelis-Menten type of kinetics have been proposed and activation parameters for the rate determining step have been computed. A mechanism consistent with the observed kinetics is proposed and discussed.