Beneficial effect on rat kidney preservation of the antiischemic agent trimetazidine during cold storage and reperfusion: Assessment by 31P nuclear magnetic resonance spectroscopy

Abstract IN RENAL transplantation, delayed graft function remains a major problem and increases the posttransplant morbidity and hospital costs. Trimetazidine (TMZ), an antiischemic drug, was introduced several years ago and used as an antianginal agent whose main effect is to be devoid of hemodynamic effects. TMZ is a cytoprotective drug that counteracts the metabolic disorders occurring at the level of ischemic cells. Several experimental results have suggested direct actions of the drug on mitochondrial function, intracellular acidosis, and calcium intracellular accumulation. 1,2 The aim of this study was to assess beneficial effect of TMZ during cold storage (CS) with Euro-Collins solution (EC) and normothermic reperfusion on energetic status of the kidneys.