Correlative study on MRI morphologic features, pathology, and molecular biology of breast cancer

OBJECTIVE   To investigate the correlation among MRI morphologic features，pathology，and molecular biology of breast cancer． METHODS  MR was usedto analyze the morphologic features of breast cancers of 78 patients before operation The mastectomy specimens of the breast neoplasms were immunohistochemically stained。and the expression of the estrogen(ER)，progesterone receptor(PR)，C-erbB-2，P53 and the distribution of microvessel density(MVD)measured The pathologic results were compared with the MRI features． RESULTS   Among the 80 breast cancers．ER positive expression was positively correlated with the spicular contour of breast cancers( P O.05)．Among 41 breast cancers examined with dynamic contrast enhanced MR．there was a positive correlation between the spatial distribution of the contrast agent and MVD ( P< O．01)． CONCLUSION  Toa certain extentthere iS some correlation among the MRI morphologic features，pathology，and molecular biologica'l factorsin breast cancer．The biological behavior and prognosis of breast cancer can be assessed based on MRI features．