Enantioselective Direct Mannich Reactions of Cyclic β-Ketoesters Catalyzed by Chiral Phosphine via a Novel Dual-Reagent Catalysis.

Yanpeng Lou,Changwu Zheng,Renming Pan,Qiao-Wen Jin,Gang Zhao,Zhong Li

Enantioselective Direct Mannich Reactions of Cyclic β-Ketoesters Catalyzed by Chiral Phosphine via a Novel Dual-Reagent Catalysis.

2015

Yanpeng Lou
Changwu Zheng
Renming Pan
Qiao-Wen Jin
Gang Zhao
Zhong Li

The combination of the chiral phosphine (PTU) and methyl acrylate efficiently catalyzes the Mannich reaction of cyclic β-ketoesters and N-Boc aldimines.

Keywords:

Enantioselective synthesis
Aldimine
Methyl acrylate
Organocatalysis
Mannich reaction
Phosphine
Chemistry
Organic chemistry
Reagent
Chirality (chemistry)

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