Intravascular ultrasound investigation with virtual hystology in the study of coronary artery lesions

: Spectral analysis of radiofrequency data obtained at intravascular ultrasound study allows to carry out more detailed analysis and morphological assessment of plaque components. In the course of preliminary investigations in vitro 4 types of reflected signals were revealed. According to results of spectral analysis of radiofrequency data these signals correspond to histological plaque components. Color coding was assigned to various components (fibrotic, fibrolipid, necrotic core, and calcinosis). Based on cluster technique invasive diagnostic intravascular ultrasound study with virtual histology allows to identify plaques of different types. It has become possible to detect criteria of plaque vulnerability. At present criteria of increased vulnerability based on histopathological studies appear to be widening of necrotic core, presence of fibrous capsule, inclusions of calcinosis, positive remodeling of coronary vascular bed, degree of stenosis, and localization of lesion.