Reduced Lipoprotein(a) Associated With the Apolipoprotein E2 Genotype Confers Cardiovascular Protection in Familial Hypercholesterolemia

There are 3 isoforms of apolipoprotein E (apo E) in humans (e2, e3, and e4). They differ by single amino acid substitutions that variably affect their affinity for the low-density lipoprotein receptor (LDLR) and for the LDLR-related protein (LRP1), with e2 having the weakest binding to these