Evaluation of tobacco use and HER2 expression in a racially and ethnically diverse inner-city population.

e11075 Background: Tobacco is the leading cause of preventable death in the United States and is linked to many cancers. Despite overwhelming biological plausibility and over four decades of epidemiological studies, no definite association has been established between tobacco and breast cancer. Ovarian, stomach, and uterine cancer are associated with tobacco consumption and these cancers express HER2. Although estrogen receptor status has been looked at as a variable there has been no evaluation of the role of her-2 and smoking in breast cancer. Methods: A retrospective review of medical records from patients treated at the University of Miami/Jackson Memorial Hospital from 1998-2009 was undertaken after IRB approval. The incidence of smoking and her-2 expression in a population of 850 women was evaluated. Data was analyzed by age, race, ethnic group, menopausal status, tumor stage and estrogen receptor. Results: 850 charts were analyzed with 720 having full information. Median age was 57(range 28 to 94)....