Design, synthesis and structure-activity relationship of novel RXR-selective modulators

Pierre-Yves Michellys,Jennifer D'Arrigo,Timothy Alan Grese,Donald S. Karanewsky,Mark D. Leibowitz,Dale A. Mais,Christopher M. Mapes,Anne Reifel Miller,Deepa Rungta,Marcus F. Boehm

Design, synthesis and structure-activity relationship of novel RXR-selective modulators

2004

Pierre-Yves Michellys
Jennifer D'Arrigo
Timothy Alan Grese
Donald S. Karanewsky
Mark D. Leibowitz
Dale A. Mais
Christopher M. Mapes
Anne Reifel Miller
Deepa Rungta
Marcus F. Boehm

The synthesis and in vitro characterization of novel RXR-selective ligands possessing various substituted 1-benzofuran or 1-benzothiophene moieties are described.

Keywords:

Benzothiophene
Ether
Biochemistry
Chemical synthesis
Organic chemistry
Stereochemistry
Structure–activity relationship
Bicyclic molecule
Ligand
Chemistry
Retinoid X receptor
design synthesis

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