Оценка эндотелиальной дисфункции и ангиогенеза у больных артериальной гипертонией с метаболическим синдромом

The goal to explore the parameters of intercellular adhesion molecules and endothelial growth factor VEGF, their relationship with endothelial dysfunction in women with arterial hypertension (AH) and metabolic syndrome (MS). Material and methods. The study included 126 women with arterial hypertension, of whom 22 had essential hypertension 1 – Grade 3 non-obese, from 104 in the presence of AH had metabolic syndrome. Women with MS were allocated into 2 groups: menopause (group 2 ) and reproductive (group 3 ). The presence of endothelial dysfunction was evaluated by studying the monocytemacrophage cytokines (G-CSF and VEGF), for expression of intercellular adhesion molecules (VCAM1, ICAM2, sPselectin), and von Willebrand factor. Results and discussion. Patients AG noted development of endothelial dysfunction, as determined by increase of local inflammation in terms of VCAM-1, G-CSF increased procoagulation components (von Willebrand factor, sP-selectin) and VEGP as factor angiogenesis. It is also noted a significant increase in polymorphic marker gene S290N SeαP (sP-selectin) and a tendency to an increase in the expression of the marker – 2578 (18) I / D gene VEGP. Increase in all indicators revealed the presence of metabolic syndrome in women, menopause proved highly significant level VEGP, VCAM-1 and sP-selectin, which allows to determine the MS and menopause as additional markers of endothelial dysfunction.