Effect of dopamine combined with norepinephrine on the renal function in patients with septic shock

Objective To investigate the effects of dopamine and norepinephrine on the renal function in the patients with septic shock. Methods Eighty-seven patients with septic shock were divided into three groups (group A, B, C) according to the biggest infusing rate of norepinephrine, with the infusing rate of 0.5～0.9, 1.0～1.5, 1.6～2.0μg·kg-1·min-1 , respectively. Mean arterial blood pressure (MAP), heart rate(HR) , urine output, blood urea nitrogen (BUN) , creatinine(CRE), urine albumin (U-ALB) and urineβ2-microglubulin(Uβ2-MG) as well as APACHEⅢscore in all the patients were detected. Results Before anti-shock therapy was given, hypotension, tachycardia and oliguria occurred in all the 87 patients, and CRE, BUN, U-ALB, Uβ2-MG and APACHEⅢscore were abnormal in most cases. With the anti-shock therapy, MAP, HR, urine output and BUN, CRE in all patients returned to normal levels gradually, and U-ALB, Uβ2-MG levels and APACHEⅢscore also restored but still remained abnormal. Conclusions The first aim of treating septic shock should be restoring the organ blood supply, and based on volume resuscitation, dopamine, noradrenaline and other vasoactive drugs could be combined to maintain circulatory stability.