Amyloidosis as a manifestation of familial mediterranean fever in siblings

Abstract This is the first report of familial mediterranean fever in two brothers (aged 12 and 10) from a middle class Muslim family in Iran, who were admitted to hospital with symptoms and signs of recurrent intermittent fever since childhood and with occasional abdominal pain and arthralgia. Exploratory laparotomy in one case revealed fibrinous peritonitis with swelling of the appendix and renal amyloidosis. In the other case needle biopsy revealed amyloidosis of the kidney.