Osteolytic femoral lesion detected by sonography in a case of light chain deposition disease

We describe a case of light chain deposition disease presenting as worsening of renal failure with a lytic femoral bone lesion discovered by sonography. Although sonography cannot be considered to be the test of choice in evaluating multiple myeloma, this technique may allow the detection and the biopsy of osteolytic bone lesions, particularly in accessible locations. Differential diagnosis is discussed. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 42:444–448, 2014