Antibiotic sensitivity of ribosomes from wild-type and clindamycin resistant Bacteroides vulgatus strains

The sensitivity to different antibiotics of in-vitro polyuridylic acid-dependent poly-peptide synthesizing system from Bacteroides vulgatus RYC18F6 and two clindamycin-resistant derivatives was studied. The ribosomes from the resistant strains were not affected by concentrations of up to 0-1 mm clindamycin and lincomycin. In contrast, streptogramin B was found to cause strong stimulation of the clindamycin-resistant polymerizing systems. The modified ribosomes from the resistant strains were more sensitive to other antibiotics like sparsomycin and chloramphenicol