Clinical aspects of the efficiency of an oral contraceptive ethynodiol diacetate bisecurin as a function of the estrogen component

105 young women (527 menstrual cycles) with normal menstrual cycles were administered the preparation Bisecurin for a period of 5 months as a contraceptive. 2 types of Bisecurin were used: ethynodiol diacetate (1 mg) and mestranol (.1 mg) in 70 women and ethynodiol diacetate (1 mg) and ethinyl estradiol (.05 mg) in 35 women. Both types of Bisecurin preparation achieved 100% effectiveness as contraceptives. No thromboembolic complications were encountered and side effects forced none of the users to discontinue use. The incidence of side effects on the part of the gastrointestinal tract of the liver and of painful swelling of the breasts was distinctly lower when the estrogen component was smaller and thus the estrogen:progestagen ratio changed in the direction of a more pronounced progestagenic climate.(Authors modified)