Differences in Raman Spectra of Aluminium Treated Brain Tissue Sample

Raman microscopy was used to measure the effect of aluminium exposure on paraffin-embedded brain tissue sections. Despite the complexity of the system, we are able to show a differential Raman spectral characteristic between the Al-treated and untreated brain tissue samples. These are attributed to changes in the packing and conformation of protein material. Much work remains to be done to quantify the effect and to optimise experimental conditions, nevertheless, the results reported here demonstrate the benefits of these Raman microspectroscopic studies in such complex biosamples.